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apalutamide will decrease the extent or influence of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a robust CYP2C19 inducer, with medicines that happen to be CYP2C19 substrates can lead to decrease publicity to those medications.diazepam will increase amounts of lomitapide by